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CNS Vital Signs (CNSVS) Computerized Neurocognitive Testing
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The CNS Vital Signs computerized neuropsychological test platform is used to measure brain function or cognitive function while examining testing effort (symptom validity) for both children and adults (ages 8 – 90 years). The test is used to rapidly evaluate and to subsequently track and manage neuropsychiatric symptoms, behaviors, and comorbidities. Results of testing are provided immediately after a test is completed and typically taken in context with other relevant clinical information such as history, physical examination, other psychological or neuropsychological tests, lab results, imaging studies, etc., in accordance with good clinical practice standards. Clinicians and researchers may choose an appropriate test set from ten normed neuropsychological tests along with an additional sixteen research subtests as well as over 50 (PRO) patient reported outcome questionnaires or instruments.

Technically, the platform runs on Windows, IOS and web environments. Response times are measured with millisecond precision. Symptom validity or invalid responses are measured as embedded indicators within the neurocognitive tests. There are an infinite number of test forms. The majority of subtests are based off of conventional “pen and paper” neuropsychological tests (e.g., the Rey Memory Test, Stroop).

Normed Subtests

 * The Verbal Memory Test measuring learning and recognition memory for words; immediate and delayed recall
 * The Visual Memory Test measuring learning and recognition memory for geometric shapes; immediate and delayed recall
 * The Finger Tapping Test measuring ability to perform hand motor movements to produce and satisfy an intention towards a manual action and goal
 * The Symbol Digit Coding Test measures ability to recognizes and processes information i.e., perceiving, attending/responding to incoming information, motor speed, fine motor coordination, and visual-perceptual ability
 * The Stroop Test measures how quickly a subject can react, in milliseconds, to a simple and increasingly complex direction set and inhibition / disinhibition of frontal or executive tasks
 * The Shifting Attention Test measures the ability to recognize and respond to rules, categories, and manages or navigates rapid decision making.
 * The CPT or Continuous Performance Test measures ability to track and respond to a single defined stimulus over lengthy periods of time while performing vigilance and response inhibition quickly and accurately.
 * The Perception of Emotions Test measures how well a subject can perceive, identify, and react to specific emotions.
 * The Non‐Verbal Reasoning Test measures how well a subject can perceive and understand the meaning of visual or abstract information and recognizing relationships between visual‐abstract concepts.
 * The Four Part CPT Test (N-Back) measures a subject's working memory or how well a subject can perceive and attend to symbols using short-term memory processes and sustained attention or how well a subject can direct and focus cognitive activity on specific stimuli.

Neurocognitive Domains

 * Complex Memory
 * Verbal Memory
 * Visual Memory
 * Psychomotor Speed
 * Reaction time
 * Complex Attention
 * Cognitive Flexibility
 * Processing speed
 * Executive function
 * Social Acuity
 * Reasoning
 * Working Memory
 * Sustained Attention
 * Visual or Simple Attention
 * Motor Speed

Patient Reported Symptoms and Outcomes Scales
Most of the 50+ (PRO) Patient Reported Outcome questionnaires or instruments made available in the in the CNS Vital Signs assessment platform are well known and were commonly used by healthcare providers as paper questionnaires. Patients self-report and rate the severity of their illness or impairment. Historically, the use of such rating scales has contributed to the assessment by ensuring thoroughness by including a patient’s subjective input of their condition, helping to facilitate the determination of response to treatment and disease course over time.

Uses for CNS Vital Signs
CNS Vital Signs is utilized by medical providers and researchers to evaluate and manage patients presenting with a psychological or neurological complaints as well as to test drug effect. CNS Vital Signs was designed to be used in busy clinical and research settings for a variety of populations such as:

Neurodegenerative Disorders (e.g., Multiple sclerosis, MCI - Mild Cognitive Impairment, Early Dementia, Epilepsy, Parkinson’s, etc.)

Neurodevelopmental Conditions (e.g., AD/HD, Asperger's, etc.)

Neuropsychiatric (e.g., Pain, Depression/Anxiety, Substance Abuse,PTSD, Eating Disorders etc.)

Neurotrauma (e.g., TBI, Brain Injury Rehabilitation Neurocognitive manifestations in conditions such as Cancer, Obesity, Post-surgery, Mild Hepatic Encephalopathy, Metabolic / Diabetes, Cardiovascular, Prion or Lyme Disease, Exercise / Human Performance, Neurotoxicity, Genetic Phenotype, Medication Effects, HIV - HAND, etc. as well as aid in the monitoring of their progression (e.g. rehabilitation), and measuring the response of the disorder to treatment.