User:Cooper lab

Cooper Lab Personnel


Juan Varela Ph.D. Research Associate Ph.D from Brandeis University 2000. Research interests include electrophysiological and computational studies studies of synaptic and intrisinc modulation of plasticity by Dopamine and its effects on behavior in the hippocampus and prefrontal cortex.

Brian Cadle BS Graduate Student

Kristin Rasmus BA Professional Research Assistant



Junli Cao Ph.D. China Medical University, 2006. Neuroadaptations of dopaminergic neurons in the ventral tegmental area underlying drug addiction and depression.

Cooper Lab Publications
Adinoff B, Devous MD Sr, Cooper DC, Best SE, Harris TS, Williams MJ. (2009) Neural response to lidocaine in healthy subjects. Psychiatry Res. Jun 26.

Hawasli A, Koovakkattu D, Hayashi K, Anderson A, Powell C, Sinton C, Bibb J., Cooper DC (2009) Regulation of hippocampal and behavioral excitability by Cyclin-dependent kinase 5. PloS One 4(6):e580.[[Media:Hawasli_et_al.,_2009.pdf|Download PDF]]

Sidiropoulou K.,Lu, FM ,Fowler M,Xiao, R, Ozkan E, Phillips C, Zhu, M.,White F.J. Cooper DC (2009) Dopamine modulation of prefrontal cortical mGluR5-mediated intrinsic regenerative activity Nat Neurosci. 12(2): 287-300. [[Media:Sidiropoulou_et_al.,_2009.pdf|Download PDF]]CNN articleBBC article

Wallace DL, Han MH, Graham DL, Green TA, Vialou V, Iñiguez SD, Cao JL, Kirk A, Chakravarty S, Kumar A, Krishnan V, Neve RL, Cooper DC, Bolaños CA, Barrot M, McClung CA, Nestler EJ. (2009) CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci. Feb;12(2):200-9.

Moore S.J. Cooper DC Spruston N. P. (2009) Bidirectional plasticity of burst firing is regulated by synergistic activation of metabotropic glutamate and acetylcholine receptors in pyramidal neurons of subiculum. Neuron 61(2):187-194.[[Media:Cooperspruston.pdf|Download PDF]]

Krishnan V, Han MH*, Graham DL, Berton O, Renthal W, Laplant Q, Graham A, Russo SJ, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Eisch AJ, Self DW, Lee FS, Tamminga C, Cooper DC, Gershenfeld HK, Nestler EJ (2007) Molecular Mechanisms of Resilience in Brain Reward Regions. Cell 131(2):391-404.

Fowler M.A. Sidiropoulou K. Phillips C. Ozkan E.. and Cooper DC (2007) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PloS One 2(6): e573[[Media:Fowler_et_al.,_2007.pdf|Download PDF]]

Hawasli A.H. Benavides D.R. Nguyen C. Kansy J.W. Hayashi K. Chambon P. Greengard P. Powell C. Cooper DC and Bibb J. (2007) Cyclin-dependent kinase 5 Governs Learning and Synaptic Plasticity via NMDA Receptors. Nat Neuroscie Epub May 27 [[Media:Hawasli_et_al_2007.pdf|Download PDF]]

Cooper DC Klipec W.D., Fowler, M, Ozkan E.D. (2006) A role for the subiculum in the brain motivation/reward circuit. Behav. Brain Res. 174(2):225-31. Epub Jul 25.

McClung C.A. Sidiropoulou, K. Vitaterna M. Takahshi J.S. White F.J. Cooper DC Nestler E. J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. PNAS 102(26):9377-81.[[Media:McClung_et_al.,2005.pdf|Download PDF]]

Cooper DC Chung S. and Spruston N. (2005) Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS Biology 3(6) e175 [[Media:Cooper_et_al.,2005.pdf|Download PDF]]News and views

Dong Y., Nasif .F, Tsui J.J., Ju W.Y., Cooper DC, Hu X-T, Malenka R.C. and White F.J. (2005) Cocaine-induced Plasticity of Intrinsic Membrane Properties in Prefrontal Cortex Pyramidal Neurons: Adaptations in Potassium Currents. J Neurosci. 26:25(4):936-40

Dong Y., Cooper DC, Nasif F., Hu XT, White F.J. (2004) Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci. 24(12):3077-85

Cooper Lab Publications Supplemental Information
ImageJ_Automatic_QRPDA_Code

IGOR_Rat_SA_Code

Neuropharmacology Course
Neuropharmacology Course

Institute for Behavioral Genetics: Cooper Lab at the Annual Poster Session
Posters: Dopamine D1R activation induces early-phase synaptic plasticity via a novel NR2B-dependent mechanism: Leah Leverich

Neuroadaptations in mesolimbic dopamine neurons mediate avoidance behavior and antidepressant actions: Junli Cao

Subunit-dependent bi-directional modification of NMDAR currents following D1R activation: Juan Varela

Cooper Lab Presentations
August 6th 1PM

Junli Cao Ph.D. will present Neuroadaptations in mesolimbic dopamine neurons mediate avoidance behavior to social defeat and antidepressant actions

Cooper Lab Journal Club
July 31

Protein kinase A regulates calcium permeability of NMDA receptors. Skeberdis VA, Chevaleyre V, Lau CG, Goldberg JH, Pettit DL, Suadicani SO, Lin Y, Bennett MV, Yuste R, Castillo PE, Zukin RS. Nat Neurosci. 2006 Apr;9(4):501-10. Epub 2006 Mar 12.

August 5

Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. Harnett MT, Bernier BE, Ahn KC, Morikawa H. Neuron. 2009 Jun 25;62(6):826-38.

August 7

Metaplastic Regulation of Long-Term Potentiation/Long-Term Depression Threshold by Activity-Dependent Changes of NR2A/NR2B Ratio

August 10

Dopamine D1R receptor activation induces synaptic plasticity via a novel NR2B dependent mechanism and promotes memory consolidation. Leah Leverich, Lane C, Varela, Cooper and Greene

August 12

Essential role for TRPC5 in amygdala function and fear-related behavior. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA Jr, Bolshakov VY, Clapham DE. Cell. 2009 May 15;137(4):761-72.

Cooper Lab Camping Retreat
We will be departing no LATER than 3PM

Please print the following paper for campfire discussion http://www.nature.com/neuro/journal/v9/n4/pdf/nn1664.pdf

The location will be Green Mountain reservoir located near Silverthorne CO.

We will be camping at the Willows which is at the far north extreme of the reservoir. [ http://www.greenmountainreservoir.com/map.htm]

Here is the weather report [ http://www.wunderground.com/US/CO/Silverthorne.html]

Here are the directions

Cooper Lab Camping Photos Image:037.JPG|everyone claimed their spot Image:049.JPG|free baby, good home Image:campinged3.jpg| everyone's favorite exothermic reaction Image:DSC0680.JPG|channing

Cooper lab Courses
Link User:Cooper_lab/Neuropharmacology