User:Nadia El Borai/publications

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Simplifying infertility treatment.
The presence of herpes simplex virus (HSV) DNA was first reported in semen and aspirates after failed in vitro embryo transfer (IVET) in 1996 by El Borai et al. The samples tested were from asymptomatic individuals attending an infertility clinic in Japan, and the HSV-DNA was detected by a nested polymerase reaction. Further reports in 1998 by El Borai et al. and confirmation of the presence of HSV-DNA in sperm was done by in-situ hybridization in Greece by Kotronias,D & N. Kapranos (1998).

Some cases of unexplained infertility could be explained by a positive test and Zovirax (acyclovir) treatment has led to successful pregnancies.

A retrospective study using HLA typing data from couples in the infertility clinic has shown that one partner had either HLA Cw3 or HLA Cw7 (100%).

The frequency for HLA Cw3 being present in a Japanese couple is 10% and the frequency in the infertile couples was 32% interestingly in the group where the aspirate of failed IVET tested positive for HSV-DNA, the frequency for Cw3 was 100%.

HLA-Cw7 was not present in any HSV-DNA positive women but in 88% of the women who tested negative for herpes DNA. Before embarking on lengthy fertility treatment, in view of these results simple antiviral therapy should be considered, especially in countries where IVET cannot be done for cultural or technical reasons.

Full paper Paper on Infertility Talk with Nadia

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Nadia El Borai 2008

List of papers
PUBLICATIONS

Yamamura M., El Borai N., Ohkubo T., Ishihara Y., Takano J., Matsunami N., Kinoshita K., Miyake T., Ohtani I., Yamazaki Y., Yamamoto M. Illustrations of the value of calorimetry in biology. Pure and Applied Chemistry, 65,1973-1977 (1993)

Ishihara Y., Ohkubo T., Shimazaki H., El Borai N., Takano J., Yamamura M., Continuous Column Culture system for Adherent Cells. Cell Biochemistry and Function, 11,221-224 (1993)

Tanaka E., Yamakawa A., Yamamura Y., El Borai N., Ito K., Nakano S., Nakazawa H. Regulation of Heat Production of brown adipocytes via typical and atypical ß-Adrenoreceptors in the Rat. Japanese Journal of Physiology,45.1043-1051 (1995)

El Borai N., Inoue M., LeFèvre C., Naumova E.N., Sato B., Yamamura M. Detection of Herpes Simplex DNA in Semen and Menstrual Blood of Individuals attending an Infertility Clinic. The Journal of Obstetrics and Gynaecology Research, 23, 17-24 (1996)

Watabe A., Ohta M., Matsuyama N., Mizuno K., El Borai N., Tanimoto T., Kawanishi T., Hayakawa T., Characterization of Plasmin-induced platelet aggregation. Research Communications in Molecular Pathology and Pharmacology, 96, 341-352 (1997)

El Borai N., LeFèvre C., Inoue M., Naumova E.N., Sato K., Suzuki S., Tsuji K., Yamamura M. Presence of HSV-1 DNA in semen and menstrual blood. Journal of Reproductive Immunology ,41, 137-147(1998)

Ohkubo T., Tsuda M., Suzuki S., El Borai N., Yamamura M.

Peripheral Blood Neutrophils of Germ-Free Rats Modified by In Vivo Granulocyte-Colony-Stimulating Factor and Exposure to Natural Environment. ''Scand. J. Immunol'', 49, 73-77, (1999).

Yu H-C., Suzuki S., Okubo T., Kawashima I., Tsuda M., El Borai N., Yamamura M. Anti-tumor effect of Chinese herbal medicines “Scutellaria barbata and Oldenlandia diffusa” on cancer cell lines and C3H-AVy mouse with spontaneous hepatocellular carcinoma. Journal of Traditional Medicines 17, 165-169 (2000)

Meetings:
1979 First Asia Oceania Histocompatibility Workshop & Conference (Japan) Oral presentation One way mixed lymphocyte reaction: A comparative study between thymidine uptake and microviscometry. El Borai N.,Inouye H., Komori K., Yamamura M., Tsuji K.

Oct. 1993 46th Japanese Cell Biology Meeting (Japan) Oral presentation

Lidocaine during liver perfusion improves hepatocyte yield and survival El Borai N., Takada S., Kusumi T., Ohkubo T., Yamamura M.

June 1994 Kanagawa Ishoku Kenkyukai (Japan) Oral presentation

Potential use of Lidocaine for organ storage at room temperature. El Borai N.,Ohkubo T., Takada S., Khilo K., Yamamura M.

Autumn 1994 2nd International Congress Pathophysiology (Kyoto, Japan) Oral presentation

Calorimetry to measure activity of cells El Borai N., Ohkubo T., Ishihara Y., Takano J., Yamamura M.

December 1996 Seminar El Borai N.  Histocompatibility & Immunogenetics Lab. Sirikit Medical Center, Ramathibodi Hospital, Bangkok, Thailand. December 1996 discussion El Borai N. Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

'''August 1997 XV FIGO World Congress of Gynecology & Obstetrics. (Copenhagen)''' Oral presentation

Diagnostic Nested PCR Assay to Detect Herpes Simplex Virus 1 DNA: Application to Menstrual Blood of Infertile Women El Borai N., Inoue M., LeFèvre C., Naumova E.N., Yamamura M., Hayakawa T.

Oct. 1997 Workshop on HIV-1 and Gametes (Siena, Italy) Aeres Serono Foundation ( Invited speaker)

Presence of HSV-1 DNA in semen and menstrual blood El Borai N., LeFèvre C., Inoue M., Naumova E.N., Sato K., Suzuki S., Tsuji K., Yamamura M.

August 1998 Third Congress of the Asia Pacific Organization for Cell Biology (Osaka, Japan) Oral presentation

Human in vitro fertilization and HSV-1 DNA El Borai N, Suzuki S., LeFèvre C., Inoue M., Naumova E.N., Sato K., Hagiwara M., Kato S., Makino T., Yamamura M.

Oct. 1998 Workshop Temple University Japan Speaker: El Borai N. Subject: To clone or not to clone?

April 1999 The 2nd International Workshop on Advanced Genomics. Genomics and Drug Discovery, Japan poster A potential reversible contraceptive vaccine for males & females El Borai N., LeFèvre C., Naumova E.N., Yamamura M.

Sept 2000 FIGO 2000 World Congress of Gynecology & Obstetrics (Washington D.C.) Chairperson and oral presentation

Herpes simplex virus in infertile couples: DNA sequence of PCR product. El Borai N., Araki M., LeFèvre C.,Naumova E.N., Inoue M., Kato S., Yamamura K., Yamamura M.

Oct. 2001 ASN/ISN World Congress of Nephrology (San Francisco, USA.) poster

Simple prognostic urine test for diabetic nephropathy: a 9 year follow-up study Yamamura M., Tetsutani T., El Borai N., Kono M., Yamaguchi T, Kiyohara S.

November 2001 The 3rd International Workshop on Advanced Genomics SNPs: Application and Related Technologies Japan poster

Silent HSV-1 and HSV-2 sequences in infertile couples El Borai N., Araki M., Suzuki T., Inoue M., Naumova E.N., LeFèvre C., Kato S., Makino T., Yamamura K., Yamamura M.

March 2002 99th Meeting for the Japanese Society of Internal Medecine poster  Clinical significance of urinary albumin in diabetic nephropathy.(translation of Japanese title) Yamamura M., Tetsutani T., Yamaguchi T., El Borai N., Kono M., Kiyohara S.

August 2002 19th Meeting of Traditional Medecines (Chiba, Japan)'''(oral presentation)

Clinical outcome of diabetic patients on Ginseng monitored by Albumin/creatinine ratio. (translation of Japanese title) Journal of Traditional Medecines vol. 19 p59 Tetsutani T., Yamaguchi T., Kiyohara S., El Borai N., Yamamura M.

April 2003 Japanese Society for Internal Medicine (Fukuoka, Japan) poster Clinical prognosis of diabetes by albumin/creatinine ratio (translation of Japanese title) Tetsutani T., Yamamura Y., El Borai N., Kono M., Yamaguchi T., Kiyohara S.

June 2003 The 5th International Workshop on Advanced Genomics  From Molecules to Systems Japan poster

Herpes simplex virus friend or foe? El Borai N., LeFèvre C., Araki M., Naumova E.N., Inoue M., Kato S., Yamamura K., Yamamura M.

April 2005 The 7th World Congress on Controversies in Obstetrics, Gynecology and Infertility Athens, Greece Simplifying Infertility Treatment (poster) Nadia El Borai, Takahiro Suzuki, Elena N. Naumova, Christophe LeFèvre, Masato Inoue, Shunichi Kato, Shun-ichiro Izumi, Masatake Araki, Ken-ichi Yamamura, Masaichi Yamamura

Hot Controversies in Infertility. Co-chairing the session

May 2005 13th World Congress on In Vitro Fertilization Assisted Reproduction & Genetics Istanbul, Turkey Optimising success for IVF (oral presentation) Nadia El Borai, Takahiro Suzuki, Elena N. Naumova, Christophe LeFèvre, Masato Inoue, Shunichi Kato, Shun-ichiro Izumi, Masatake Araki, Ken-ichi Yamamura, Masaichi Yamamura

November 2007 The 7th International Worshop on Advanced Genomics Tokyo Japan (poster)

Human Herpes Virus selected and confirmed by comparative genomics and sequencing in infertile individuals Nadia El Borai, Christophe LeFèvre, Masato Inoue, Shun-ichiro Izumi, Takahiro Suzuki, Masatake Araki, Ken-ichi Yamamura, Masaichi Yamamura

May 2009 Xianmen Hospital of TCM Nadia El Borai Lecture in English What can be done for infertility of unknown cause

June 2009 Rencontre Scientifique Francophone de Tokyo (RSFT) at Maison franco-Japonaise MFJ Nadia El Borai talk in French "Mon expérience de recherche au Japon en particulier concernant l'infertilité"